This guideline offers evidence-based protocols that can be individualized to an infant’s abilities (infant-directed) and acknowledge the family as the primary caregiver and feeder (family-centered). Guidance is provided for nurses to help parents interpret infant cues during feeding, problem solve infant behavior issues, and explore interventions to support the infant’s self-regulation throughout feedings. Based heavily on the literature, this guideline offers a consistent approach and language for all caregivers, including family members, in the pursuit of optimal oral feeding outcomes.